Glutamate receptors, also known as GluRs, are a diverse group that mediates most of the excitatory synaptic communication in the CNS of vertebrates. They can be classified as ionotropic, metabotropic, and subcategorized according to their agonist preferences.
There are four types of AMPA selective GluR subunits, GluR1, GluR2, GluR3 or GluR4. Functional diversity is achieved by the use of tetrameric and pentameric combinations from different subunits. GluR1 (glutamate-receptor 1) is an ionotropic glutamate receiver. You can know more about gluR1-Antibody via the internet.
L-glutamate is an excitatory neurotransmitter that acts at multiple synapses of the central nervous system. The binding of L-glutamate to the excitatory neurotransmitter L-glutamate causes a conformational change which leads to the opening and conversion of the chemical signal into an electrical impulse.
The receptor becomes transiently inactive when it is surrounded by an agonist. The presence of CACNG4, CACNG7 or CACNG8 causes resensitization. This is due to a delayed accumulation and decrease in current flux after continued use of glutamate.
Glutamate activates two types of ion channels. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) are known as AMPA receptors (AMPAR).
The four subunits of the AMPA glutamate receptor subunits (GluR1-4), play important roles in almost all excitatory neurotransmission in the brain.